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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Organotin(IV)‐Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment
|
|---|---|
| Published in |
Angewandte Chemie. International Edition, May 2014
|
| DOI | 10.1002/anie.201400763 |
| Pubmed ID | |
| Authors |
Mirna Z. Bulatović, Danijela Maksimović‐Ivanić, Christian Bensing, Santiago Gómez‐Ruiz, Dirk Steinborn, Harry Schmidt, Marija Mojić, Aleksandra Korać, Igor Golić, Damian Pérez‐Quintanilla, Miljana Momčilović, Sanja Mijatović, Goran N. Kaluđerović |
| Abstract |
The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 3% |
| Greece | 1 | 3% |
| Unknown | 33 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 20% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 3 | 9% |
| Researcher | 3 | 9% |
| Student > Doctoral Student | 2 | 6% |
| Other | 7 | 20% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 15 | 43% |
| Agricultural and Biological Sciences | 3 | 9% |
| Computer Science | 1 | 3% |
| Immunology and Microbiology | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 10 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2014.
All research outputs
#3,713,898
of 25,394,764 outputs
Outputs from Angewandte Chemie. International Edition
#11,910
of 50,044 outputs
Outputs of similar age
#35,862
of 241,883 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#162
of 689 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 50,044 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,883 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 689 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.