| Title |
Insights from zebrafish on human pigment cell disease and treatment
|
|---|---|
| Published in |
Developmental Dynamics, August 2017
|
| DOI | 10.1002/dvdy.24550 |
| Pubmed ID | |
| Authors | |
| Abstract |
Black pigment cells, melanocytes, arise early during development from multipotent neural crest cells. Melanocytes protect human skin from DNA damaging sunrays and provide color for hair, eyes and skin. Several disorders and diseases originate from these cells, including the deadliest skin cell cancer, melanoma. Thus, melanocytes are critical for a healthy life and for protecting humans from disease. Due to the ease of visualizing pigment cells through transparent larvae skin and conserved roles for zebrafish melanophore genes to mammalian melanocyte genes, zebrafish larvae offer a biologically relevant model for understanding pigment cell development and disease in humans. This review discusses our current knowledge of melanophore biology and how zebrafish are contributing to improving how diseases of melanocytes are understood and treated in humans. This article is protected by copyright. All rights reserved. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 17% |
| Student > Bachelor | 7 | 13% |
| Researcher | 6 | 11% |
| Student > Master | 4 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 20 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 28% |
| Agricultural and Biological Sciences | 9 | 17% |
| Neuroscience | 3 | 6% |
| Arts and Humanities | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 21 | 39% |