Background -Excessive sedentary time is ubiquitous in developed nations and is associated with deleterious health outcomes. Few studies have examined whether the manner in which sedentary time is accrued (in short or long bouts) carries any clinical relevance. The purpose of this study was to examine the association of prolonged-uninterrupted sedentary behavior with glycemic biomarkers in a cohort of U.S. Hispanic/Latino adults. Methods -We studied 12,083 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a population-based study of Hispanic/Latino adults 18-74 years. Homeostatic model assessment of insulin resistance (HOMA-IR) and glycosylated hemoglobin (Hb1Ac) were measured from a fasting blood sample and 2-hour glucose was measured following an oral glucose tolerance test. Sedentary time was objectively measured using a hip-mounted accelerometer. Prolonged, uninterrupted sedentariness was expressed as mean sedentary bout length. Results -Adjusted for potential confounders and moderate-vigorous physical activity, longer sedentary bout duration was dose-dependently associated with increased HOMA-IR (p-trend <0.001) and 2-hour glucose levels (p-trend=0.015). These associations were not independent of total sedentary time, however a significant interaction between sedentary bout duration and total sedentary time was observed. Evaluation of the joint association of total sedentary time and sedentary bout duration showed that participants in the upper quartile for both sedentary characteristics (i.e. high total sedentary time and high sedentary bout duration) had the highest levels of HOMA-IR (p<0.001 vs. low group for both sedentary characteristics) and 2-hour glucose (p=0.002 vs. low group for both sedentary characteristics). High total sedentary time or high sedentary bout duration alone were not associated with differences in any glycemic biomarkers. Conclusions -Accruing sedentary time in prolonged, uninterrupted bouts may be deleteriously associated with biomarkers of glucose regulation.
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2021.
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#797,880
of 34,189,040 outputs
Outputs from Circulation
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#12,448
of 355,961 outputs
Outputs of similar age from Circulation
#32
of 184 outputs
Altmetric has tracked 34,189,040 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 28,251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.3. This one has done particularly well, scoring higher than 92% of its peers.
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