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A chemical shift encoding (CSE) approach for spectral selection in fluorine‐19 MRI

Overview of attention for article published in Magnetic Resonance in Medicine, August 2017
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Article details
Title
A chemical shift encoding (CSE) approach for spectral selection in fluorine‐19 MRI
Published in
Magnetic Resonance in Medicine, August 2017
DOI 10.1002/mrm.26874
Pubmed ID
Authors
Abstract

To develop a chemical shift encoding (CSE) approach for fluorine-19 MRI of perfluorocarbons in the presence of multiple known fluorinated chemical species. A multi-echo CSE technique is applied for spectral separation of the perfluorocarbon perfluoro-15-crown-5-ether (PFCE) and isoflurane (ISO) based on their chemical shifts at 4.7 T. Cramér-Rao lower bound analysis is used to identify echo combinations with optimal signal-to-noise performance. Signal contributions are fit with a multispectral fluorine signal model using a non-linear least squares estimation reconstruction directly from k-space data. This CSE approach is tested in fluorine-19 phantoms and in a mouse with a 2D and 3D spoiled gradient-echo acquisition using multiple echo times determined from Cramér-Rao lower bound analysis. Cramér-Rao lower bound analysis for PFCE and ISO separation shows signal-to-noise performance is maximized with a 0.33 ms echo separation. A linear behavior (R(2)  = 0.987) between PFCE signal and known relative PFCE volume is observed in CSE reconstructed images using a mixed PFCE/ISO phantom. Effective spatial and spectral separation of PFCE and ISO is shown in phantoms and in vivo. Feasibility of a gradient-echo CSE acquisition and image reconstruction approach with optimized noise performance is demonstrated through fluorine-19 MRI of PFCE with effective removal of ISO signal contributions. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

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Geographical breakdown

Geographical breakdown
Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status
Readers by professional status Count As %
Student > Ph. D. Student 8 32%
Researcher 5 20%
Student > Doctoral Student 3 12%
Student > Master 2 8%
Other 1 4%
Other 0 0%
Unknown 6 24%
Readers by discipline
Readers by discipline Count As %
Chemistry 5 20%
Physics and Astronomy 3 12%
Medicine and Dentistry 3 12%
Agricultural and Biological Sciences 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 3 12%
Unknown 8 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2017.
All research outputs
#20,444,703
of 22,999,744 outputs
Outputs from Magnetic Resonance in Medicine
#6,068
of 6,846 outputs
Outputs of similar age
#277,223
of 317,366 outputs
Outputs of similar age from Magnetic Resonance in Medicine
#70
of 107 outputs
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