The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for Vaccine Design

Overview of attention for article published in Cell Host & Microbe (Science Direct), June 2014

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RT @victornizet: @DrNeilStone Discovery of the genetic basis and virulence function of the eponymous, species-defining, Lancefield Group A…

@DrNeilStone Discovery of the genetic basis and virulence function of the eponymous, species-defining, Lancefield Group A carbohydrate antigen (which makes up ~40% of the cell wall) by @N_van_sorge and Jason Cole and how it can be exploited as a vaccine…

We extracted GAC lacking GlcNAc (say that 5 times fast) from GAS strains lacking gacI, the enzyme that helps decorate GAC with GlcNAc. (Strain also lacked the hyaluronan capsule for cleaner preps.) See this paper from Nina van Sorge for more details: ht…

Harkens back to Nina and Jason's @cellhostmicrobe paper https://t.co/oKjLC57bSs https://t.co/ScTSsZrUjz

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