Attention for Chapter:
Direct Interactions of Cholesterol With Pentameric Ligand-Gated Ion Channels: Testable Hypotheses From Computational Predictions
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Average Attention Score compared to outputs of the same age and source
Several essential ionotropic neurotransmitter receptors, including the nicotinic acetylcholine receptor (nAChR) and gamma-aminobutyric acid (GABA) type A receptor (GABAAr), belong to the family of pentameric ligand-gated ion channels (pLGICs). Function of these receptors is particularly sensitive to their lipid environment, including cholesterol and cholesterol-derived neurosteroids. Direct structural data investigating interactions between sterols and pLGICs, as well as their role in modulatory mechanisms, are largely unavailable. Physics-based computational approaches can serve a vital role in interpretation of more indirect data as well as hypothesis generation and experimental design. In this chapter, I report several examples in which computational approaches were used to predict direct binding interactions of steroids and pLGICs, evaluate the relative likelihood of possible interpretations of experimental data, and present rationally designed simple experiments. I conclude by offering several predictions that could be tested by future experiments.
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#20,667,437
of 32,387,433 outputs
Outputs from Current topics in membranes
#82
of 158 outputs
Outputs of similar age
#263,701
of 448,662 outputs
Outputs of similar age from Current topics in membranes
#8
of 13 outputs
Altmetric has tracked 32,387,433 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 158 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,662 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
