Noncoding RNAs (ncRNAs) are coded by 98% of the human genomic DNA. They are grouped into two major classes according to their length: small ncRNAs and long ncRNAs. They regulate genome organization and stability, and physiological processes that maintain cellular homeostasis. Recently, there has emerged a large interest in ncRNAs because of their significant roles in the development of several inflammatory diseases, including sarcoidosis. Some of them were introduced as novel markers for the disease activity, such increased levels of miRNA-34a that was found in peripheral blood mononuclear cells of sarcoidosis patients reemphasizing the inflammatory component in sarcoidosis. They are also important key factors in the outcome of sarcoidosis. Dysregulation of miRNA-let7f leads to overexpression of profibrotic factors and could be related to the pathogenesis of pulmonary fibrosis in patients with sarcoidosis due to the positive effect on collagen expression and deposition. However, many unanswered questions remain about the association of ncRNAs and sarcoidosis. By understanding the functions of ncRNAs in Th1 and Th-17 cells, we may be able to uncover the mechanism of action of those cells in sarcoidosis. The diagnostic potential in noncoding RNA is remarkable. Indeed, further translational research is needed to define the RNA gene fingerprint of different sarcoidosis stages.
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2018.
All research outputs
#5,085,141
of 30,092,955 outputs
Outputs from American Journal of Respiratory Cell and Molecular Biology
#426
of 3,923 outputs
Outputs of similar age
#84,328
of 456,745 outputs
Outputs of similar age from American Journal of Respiratory Cell and Molecular Biology
#8
of 57 outputs
Altmetric has tracked 30,092,955 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,923 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 456,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.
