Post-traumatic stress disorder (PTSD) is characterized by a failure of psychological recovery from a traumatic experience. At a neural level, it is associated with abnormalities of the areas of the neural system that process threatening information, including the amygdala and medial-prefrontal cortex, as well as of that involved in episodic memory, including the hippocampus. However, little is known about how the function of these regions may change as one recovers from the disorder. In this investigation, PTSD patients underwent two functional magnetic resonance imaging (fMRI) scans, 6-9 months apart, while viewing fearful and neutral faces in preparation for a memory test (administered outside the scanner). At Time 2, 65% of patients were in remission. Current symptom levels correlated positively with memory-related fMRI activity in the amygdala and ventral-medial prefrontal cortex (vmPFC). In addition, the change in activity within the hippocampus and the subgenual anterior cingulate cortex (sgACC) was associated with the degree of symptom improvement (n=18). These results suggest differential involvement of structures within the fear network in symptom manifestation and in recovery from PTSD: whereas activity within the amygdala and vmPFC appeared to be a marker of current symptom severity, functional changes in the hippocampus and sgACC reflected recovery. These results underscore the importance of longitudinal investigations for the identification of the differential neural structures associated with the expression and remission of anxiety disorders.
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2020.
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#4,759,367
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Outputs from Neuropsychologia
#935
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Outputs of similar age
#22,630
of 119,990 outputs
Outputs of similar age from Neuropsychologia
#11
of 45 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,173 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one has done well, scoring higher than 77% of its peers.
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We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.
