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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunological Identification of Vesicular Nucleotide Transporter in Intestinal L Cells
|
|---|---|
| Published in |
Biological and Pharmaceutical Bulletin, January 2014
|
| DOI | 10.1248/bpb.b14-00275 |
| Pubmed ID | |
| Authors |
Yuika Harada, Miki Hiasa |
| Abstract |
It is well established that vesicular nucleotide transporter (VNUT) is responsible for vesicular storage of nucleotides such as ATP, and that VNUT-expressing cells can secrete nucleotides upon exocytosis, playing an important role in purinergic chemical transmission. In the present study, we show that VNUT is expressed in intestinal L cells. Immunohistochemical evidence indicated that VNUT is present in glucagon-like peptide 1 (GLP-1) containing cells in rat intestine. VNUT immunoreactivity is not co-localized with GLP-1, a marker for secretory granules, and synaptophysin, a marker for synaptic-like microvesicles (SLMVs). Essentially the same results were obtained for GLUTag clonal L cells. Sucrose density gradient analysis confirmed that VNUT is present the light fraction, unlike secretory granules. These results demonstrate that intestinal L cells express VNUT in either the unidentified organelles at light density other than secretory granules and SLMVs or a subpopulation of SLMVs, and suggest that L cells are purinergic in nature and secrete nucleotides independent of GLP-1 secretion. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 25% |
| Student > Bachelor | 4 | 20% |
| Student > Doctoral Student | 3 | 15% |
| Professor | 2 | 10% |
| Lecturer | 1 | 5% |
| Other | 4 | 20% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 30% |
| Agricultural and Biological Sciences | 5 | 25% |
| Medicine and Dentistry | 4 | 20% |
| Neuroscience | 2 | 10% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 1 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2014.
All research outputs
#20,232,430
of 22,758,248 outputs
Outputs from Biological and Pharmaceutical Bulletin
#2,572
of 2,945 outputs
Outputs of similar age
#264,801
of 305,266 outputs
Outputs of similar age from Biological and Pharmaceutical Bulletin
#67
of 78 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,945 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.