| Title |
Clinical significance of epithelial‐mesenchymal transition
|
|---|---|
| Published in |
Clinical and Translational Medicine, July 2014
|
| DOI | 10.1186/2001-1326-3-17 |
| Pubmed ID | |
| Authors |
Konrad Steinestel, Stefan Eder, Andres Jan Schrader, Julie Steinestel |
| Abstract |
The concept of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research community. Thousands of scientific reports investigated changes in gene, mRNA and protein expression compatible with EMT and their possible correlation with tumor invasion, metastatic spread or patient prognosis; however, up to now, a proof of clinical significance of the concept is still missing. This review, with a main focus on the role of EMT in tumors, will summarize the basic molecular events underlying EMT including the signaling pathways capable of its induction as well as changes in EMT-associated protein expression and will very briefly touch the role of microRNAs in EMT. We then outline protein markers that are used most frequently for the assessment of EMT in research and diagnostic evaluation of tumor specimens and depict the link between EMT, a cancer stem cell (CSC) phenotype and resistance to conventional antineoplastic therapies. Furthermore, we evaluate a possible correlation between EMT marker expression and patient prognosis as well as current therapeutic concepts targeting the EMT process to slow down or prevent metastatic spread of malignant tumors. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | <1% |
| Brazil | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Philippines | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 174 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 26% |
| Researcher | 24 | 13% |
| Student > Bachelor | 19 | 11% |
| Student > Master | 18 | 10% |
| Student > Doctoral Student | 15 | 8% |
| Other | 36 | 20% |
| Unknown | 22 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 25% |
| Agricultural and Biological Sciences | 45 | 25% |
| Biochemistry, Genetics and Molecular Biology | 41 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Immunology and Microbiology | 3 | 2% |
| Other | 13 | 7% |
| Unknown | 29 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2014.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Clinical and Translational Medicine
#571
of 1,060 outputs
Outputs of similar age
#145,690
of 242,138 outputs
Outputs of similar age from Clinical and Translational Medicine
#8
of 10 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,060 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.