In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and significantly associated with CD4(+) T cell activation and viral load. Our data are among the first to demonstrate the dynamic nature of host restriction factors in vivo over time.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2014.
All research outputs
#21,320,623
of 26,184,649 outputs
Outputs from Journal of Virology
#24,286
of 26,345 outputs
Outputs of similar age
#179,522
of 243,551 outputs
Outputs of similar age from Journal of Virology
#185
of 225 outputs
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