Limited understanding of what protects from HIV hinders development of an efficacious vaccine. Lehner and colleagues now report that vaginal immunization with an HIVgp140 vaccine linked to the 70kD heat shock protein down-regulated the HIV co-receptor, CCR5, and increased expression of the HIV resistance factor, APOBEC3G, in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity - they may prove to be critical for preventing HIV transmission.
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2014.
All research outputs
#22,579,355
of 34,217,933 outputs
Outputs from Journal of Virology
#26,040
of 30,537 outputs
Outputs of similar age
#167,863
of 274,393 outputs
Outputs of similar age from Journal of Virology
#166
of 219 outputs
Altmetric has tracked 34,217,933 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 30,537 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,393 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 219 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
