| Title |
FRIENDLY Regulates Mitochondrial Distribution, Fusion, and Quality Control in Arabidopsis
|
|---|---|
| Published in |
Plant Physiology, August 2014
|
| DOI | 10.1104/pp.114.243824 |
| Pubmed ID | |
| Authors |
Amr M. El Zawily, Markus Schwarzländer, Iris Finkemeier, Iain G. Johnston, Abdelilah Benamar, Yongguo Cao, Clémence Gissot, Andreas J. Meyer, Ken Wilson, Raju Datla, David Macherel, Nick S. Jones, David C. Logan |
| Abstract |
Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically and dynamically from those in other eukaryotes. FRIENDLY, a member of the clu-superfamily, is conserved amongst eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY function leads to mitochondrial clustering and the effects of this aberrant chondriome on cell and whole plant physiology. We present evidence for a role of FRIENDLY in mediating inter-mitochondrial association, which is a necessary prelude to mitochondrial fusion. We demonstrate that disruption of mitochondrial association, motility, and chondriome structure in friendly affects mitochondrial quality control, and leads to mitochondrial stress, cell death and strong growth phenotypes. |
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Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 99 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 25% |
| Researcher | 10 | 10% |
| Student > Doctoral Student | 9 | 9% |
| Professor | 9 | 9% |
| Student > Bachelor | 5 | 5% |
| Other | 12 | 12% |
| Unknown | 32 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 38 | 37% |
| Biochemistry, Genetics and Molecular Biology | 23 | 22% |
| Medicine and Dentistry | 2 | 2% |
| Mathematics | 1 | <1% |
| Immunology and Microbiology | 1 | <1% |
| Other | 2 | 2% |
| Unknown | 36 | 35% |