Title |
Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies
|
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Published in |
Oxidative Medicine & Cellular Longetivity, May 2014
|
DOI | 10.1155/2014/541230 |
Pubmed ID | |
Authors |
Giovanni Pagano, Annarita Aiello Talamanca, Giuseppe Castello, Mario D. Cordero, Marco d’Ischia, Maria Nicola Gadaleta, Federico V. Pallardó, Sandra Petrović, Luca Tiano, Adriana Zatterale |
Abstract |
Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | <1% |
Germany | 1 | <1% |
Unknown | 138 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 24% |
Student > Ph. D. Student | 20 | 14% |
Student > Bachelor | 14 | 10% |
Student > Master | 12 | 9% |
Other | 8 | 6% |
Other | 25 | 18% |
Unknown | 28 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 32 | 23% |
Agricultural and Biological Sciences | 26 | 19% |
Biochemistry, Genetics and Molecular Biology | 21 | 15% |
Nursing and Health Professions | 8 | 6% |
Chemistry | 6 | 4% |
Other | 19 | 14% |
Unknown | 28 | 20% |