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Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol.

Overview of attention for article published in Current Pharmaceutical Biotechnology, January 2014
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol.
Published in
Current Pharmaceutical Biotechnology, January 2014
DOI 10.2174/138920101506140910152253
Pubmed ID
Authors

Boris Pejin, Carmine Iodice, Giuseppina Tommonaro, Bojana Stanimirovic, Ana Ciric, Jasmina Glamoclija, Milos Nikolic, Salvatore De Rosa, Marina Sokovic

Abstract

This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
United States 1 4%
Serbia 1 4%
Unknown 21 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 25%
Student > Ph. D. Student 4 17%
Student > Master 3 13%
Student > Doctoral Student 2 8%
Professor 2 8%
Other 3 13%
Unknown 4 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 33%
Immunology and Microbiology 3 13%
Biochemistry, Genetics and Molecular Biology 2 8%
Chemistry 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 4 17%
Unknown 4 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2014.
All research outputs
#17,289,387
of 25,377,790 outputs
Outputs from Current Pharmaceutical Biotechnology
#571
of 995 outputs
Outputs of similar age
#202,818
of 319,301 outputs
Outputs of similar age from Current Pharmaceutical Biotechnology
#23
of 61 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 995 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,301 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.