A detailed understanding of the mechanism of organic cocrystal formation remains elusive. Techniques that interrogate a reacting system in situ are preferred, though experimentally challenging. We report here the results of a solid-state in situ NMR study of the spontaneous formation of a cocrystal between a pharmaceutical mimic (caffeine) and a coformer (malonic acid). Using (13)C magic angle spinning NMR, we show that the formation of the cocrystal may be tracked in real time. We find no direct evidence for a short-lived, chemical shift-resolved amorphous solid intermediate. However, changes in the line width and line center of the malonic acid methylene resonance, in the course of the reaction, provide subtle clues to the mode of mass transfer that underlies cocrystal formation.
Pharmacology, Toxicology and Pharmaceutical Science
5
8%
Medicine and Dentistry
4
6%
Physics and Astronomy
3
5%
Materials Science
3
5%
Other
6
9%
Unknown
21
32%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#22,751,409
of 32,950,213 outputs
Outputs from The Journal of Physical Chemistry Letters
#5,541
of 9,308 outputs
Outputs of similar age
#167,271
of 264,799 outputs
Outputs of similar age from The Journal of Physical Chemistry Letters
#52
of 100 outputs
Altmetric has tracked 32,950,213 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,308 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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