We report herein that 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) can directly reach an electronically excited state upon light absorption and trigger the generation of C(sp3)-centered radicals without the need for an external photocatalyst. Selective excitation with a violet-light-emitting diode turns alkyl-DHPs into strong reducing agents that can activate reagents via single-electron transfer manifolds while undergoing a homolytic cleavage to generate radicals. We used this photochemical dual-reactivity profile to trigger radical-based carbon-carbon bond-forming processes, including nickel catalyzed cross-coupling reactions.
Pharmacology, Toxicology and Pharmaceutical Science
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Agricultural and Biological Sciences
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Other
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Unknown
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32%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2019.
All research outputs
#3,226,304
of 34,372,222 outputs
Outputs from Angewandte Chemie. International Edition
#7,175
of 61,697 outputs
Outputs of similar age
#45,839
of 371,760 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#148
of 790 outputs
Altmetric has tracked 34,372,222 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 61,697 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,760 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 790 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.
