| Title |
Central nervous system complications after allogeneic hematopoietic stem cell transplantation
|
|---|---|
| Published in |
Future Oncology, October 2017
|
| DOI | 10.2217/fon-2017-0274 |
| Pubmed ID | |
| Authors |
Ranjit Kumar Chaudhary, Prajwal Dhakal, Aashrayata Aryal, Vijaya Raj Bhatt |
| Abstract |
Allogenic hematopoietic stem cell transplant (alloSCT) is a potentially curative modality of treatment for patients with hematological malignancies. However, CNS complications following transplant pose a risk to survival of the patients. Early recognition and management of these complications are crucial to reduce morbidity and mortality of patients following transplant. Early CNS complications associated with alloSCT are infection, cerebrovascular events, chemotherapy and radiation-induced toxicities while late complications include post-transplant lymphoproliferative disorder, CNS relapse of underlying malignancy and viral and fungal infections. Development of graft-versus-host disease can further increase the risk of CNS complications and outcomes after alloSCT. Strategies aimed to reduce the risk of CNS complications and early management may ameliorate the morbidity and mortality in transplant recipients. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 13% |
| Student > Doctoral Student | 4 | 9% |
| Researcher | 4 | 9% |
| Other | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 6 | 13% |
| Unknown | 19 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 31% |
| Neuroscience | 5 | 11% |
| Arts and Humanities | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 5 | 11% |
| Unknown | 18 | 40% |