Antidepressant medication use (ADM) has been shown to predict diabetes. This paper assessed the role of inflammatory markers in this relationship within the Diabetes Prevention Program (DPP).
DPP participants randomized to Metformin (MET), Lifestyle Intervention (ILS) or placebo (PLB) were assessed for depression (BDI; Beck Depression Inventory) annually; ADM use semi-annually; serum inflammatory markers (CRP, IL-6) at baseline and Year 1; and diagnosis of T2DM semi-annually (over 3.2 years).
At baseline (N=3,187), mean BMI was 34 kg/m (S.D. 6) and the median BDI score was 3 [interquartile range: 1-7]. 181 (5.7%) reported ADM use and 328 (10%) had BDI scores of >11. CRP and IL-6 levels did not differ by treatment group.Baseline ADM, but not BDI score, was associated with higher levels of baseline CRP adjusted for demographic, anthropometric variables, and other medications (20% higher, p=0.01). Year 1 CRP decreased for non-ADM users in the MET (-13.2%) and ILS (-34%) groups and ADM users in the ILS group (-29%). No associations were found with IL-6.CRP and continuous use of ADM predicted incident T2DM in the PLB group. In the ILS group, continuous and intermittent ADM, but not CRP, predicted T2DM. In the MET group, CRP predicted incident T2DM. CRP did not mediate the risk of T2DM with ADM use in any group.
ADM was significantly associated with elevated CRP and incident T2DM. In the PLB group, ADM and CRP independently predicted onset of T2DM, however CRP did not significantly mediate the effect of ADM.
Pharmacology, Toxicology and Pharmaceutical Science
2
1%
Other
10
7%
Unknown
65
48%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2017.
All research outputs
#21,315,866
of 34,411,289 outputs
Outputs from Biopsychosocial Science and Medicine (BSAM)
#2,084
of 2,913 outputs
Outputs of similar age
#279,235
of 492,533 outputs
Outputs of similar age from Biopsychosocial Science and Medicine (BSAM)
#19
of 33 outputs
Altmetric has tracked 34,411,289 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,913 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.3. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
