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Mendeley readers
| Title |
Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity
|
|---|---|
| Published in |
Food Chemistry, July 2012
|
| DOI | 10.1016/j.foodchem.2012.07.091 |
| Pubmed ID | |
| Authors |
Vassiliki G. Kontogianni, Goran Tomic, Ivana Nikolic, Alexandra A. Nerantzaki, Nisar Sayyad, Stanislava Stosic-Grujicic, Ivana Stojanovic, Ioannis P. Gerothanassis, Andreas G. Tzakos |
| Abstract |
The goal of this study was to monitor the anti-proliferative activity of Rosmarinus officinalis and Salvia officinalis extracts against cancer cells and to correlate this activity with their phytochemical profiles using liquid chromatography/diode array detection/electrospray ion trap tandem mass spectrometry (LC/DAD/ESI-MS(n)). For the quantitative estimation of triterpenic acids in the crude extracts an NMR based methodology was used and compared with the HPLC measurements, both applied for the first time, for the case of betulinic acid. Both extracts exerted cytotoxic activity through dose-dependent impairment of viability and mitochondrial activity of rat insulinoma m5F (RINm5F) cells. Decrease of RINm5F viability was mediated by nitric oxide (NO)-induced apoptosis. Importantly, these extracts potentiated NO and TNF-α release from macrophages therefore enhancing their cytocidal action. The rosemary extract developed more pronounced antioxidant, cytotoxic and immunomodifying activities, probably due to the presence of betulinic acid and a higher concentration of carnosic acid in its phytochemical profile. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Bosnia and Herzegovina | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 388 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 3 | <1% |
| Malaysia | 1 | <1% |
| India | 1 | <1% |
| Croatia | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 381 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 70 | 18% |
| Researcher | 51 | 13% |
| Student > Master | 51 | 13% |
| Student > Bachelor | 33 | 9% |
| Student > Doctoral Student | 25 | 6% |
| Other | 51 | 13% |
| Unknown | 107 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 89 | 23% |
| Chemistry | 45 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 38 | 10% |
| Biochemistry, Genetics and Molecular Biology | 34 | 9% |
| Medicine and Dentistry | 20 | 5% |
| Other | 42 | 11% |
| Unknown | 120 | 31% |