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X Demographics
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Attention Score in Context
| Title |
Characterization of HPV and host genome interactions in primary head and neck cancers
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, October 2014
|
| DOI | 10.1073/pnas.1416074111 |
| Pubmed ID | |
| Authors |
Michael Parfenov, Chandra Sekhar Pedamallu, Nils Gehlenborg, Samuel S. Freeman, Ludmila Danilova, Christopher A. Bristow, Semin Lee, Angela G. Hadjipanayis, Elena V. Ivanova, Matthew D. Wilkerson, Alexei Protopopov, Lixing Yang, Sahil Seth, Xingzhi Song, Jiabin Tang, Xiaojia Ren, Jianhua Zhang, Angeliki Pantazi, Netty Santoso, Andrew W. Xu, Harshad Mahadeshwar, David A. Wheeler, Robert I. Haddad, Joonil Jung, Akinyemi I. Ojesina, Natalia Issaeva, Wendell G. Yarbrough, D. Neil Hayes, Jennifer R. Grandis, Adel K. El-Naggar, Matthew Meyerson, Peter J. Park, Lynda Chin, J. G. Seidman, Peter S. Hammerman, Raju Kucherlapati, Adrian Ally, Miruna Balasundaram, Inanc Birol, Reanne Bowlby, Yaron S.N. Butterfield, Rebecca Carlsen, Dean Cheng, Andy Chu, Noreen Dhalla, Ranabir Guin, Robert A. Holt, Steven J.M. Jones, Darlene Lee, Haiyan I. Li, Marco A. Marra, Michael Mayo, Richard A. Moore, Andrew J. Mungall, A. Gordon Robertson, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Tina Wong, Alexei Protopopov, Netty Santoso, Semin Lee, Michael Parfenov, Jianhua Zhang, Harshad S. Mahadeshwar, Jiabin Tang, Xiaojia Ren, Sahil Seth, Psalm Haseley, Dong Zeng, Lixing Yang, Andrew W. Xu, Xingzhi Song, Angeliki Pantazi, Christopher Bristow, Angela Hadjipanayis, Jonathan Seidman, Lynda Chin, Peter J. Park, Raju Kucherlapati, Rehan Akbani, Tod Casasent, Wenbin Liu, Yiling Lu, Gordon Mills, Thomas Motter, John Weinstein, Lixia Diao, Jing Wang, You Hong Fan, Jinze Liu, Kai Wang, J. Todd Auman, Saianand Balu, Tom Bodenheimer, Elizabeth Buda, D. Neil Hayes, Katherine A. Hoadley, Alan P. Hoyle, Stuart R. Jefferys, Corbin D. Jones, Patrick K. Kimes, J.S. Marron, Shaowu Meng, Piotr A. Mieczkowski, Lisle E. Mose, Joel S. Parker, Charles M. Perou, Jan F. Prins, Jeffrey Roach, Yan Shi, Janae V. Simons, Darshan Singh, Mathew G. Soloway, Donghui Tan, Umadevi Veluvolu, Vonn Walter, Scot Waring, Matthew D. Wilkerson, Junyuan Wu, Ni Zhao, Andrew D. Cherniack, Peter S. Hammerman, Aaron D. Tward, Chandra Sekhar Pedamallu, Gordon Saksena, Joonil Jung, Akinyemi I. Ojesina, Scott L. Carter, Travis I. Zack, Steven E. Schumacher, Rameen Beroukhim, Samuel S. Freeman, Matthew Meyerson, Juok Cho, Lynda Chin, Gad Getz, Michael S. Noble, Daniel DiCara, Hailei Zhang, David I. Heiman, Nils Gehlenborg, Doug Voet, Pei Lin, Scott Frazer, Petar Stojanov, Yingchun Liu, Lihua Zou, Jaegil Kim, Michael S. Lawrence, Carrie Sougnez, Lee Lichtenstein, Kristian Cibulskis, Eric Lander, Stacey B. Gabriel, Donna Muzny, HarshaVardhan Doddapaneni, Christie Kovar, Jeff Reid, Donna Morton, Yi Han, Walker Hale, Hsu Chao, Kyle Chang, Jennifer A. Drummond, Richard A. Gibbs, Nipun Kakkar, David Wheeler, Liu Xi, Giovanni Ciriello, Marc Ladanyi, William Lee, Ricardo Ramirez, Chris Sander, Ronglai Shen, Rileen Sinha, Nils Weinhold, Barry S. Taylor, B. Arman Aksoy, Gideon Dresdner, Jianjiong Gao, Benjamin Gross, Anders Jacobsen, Boris Reva, Nikolaus Schultz, S. Onur Sumer, Yichao Sun, Timothy Chan, Luc Morris, Joshua Stuart, Stephen Benz, Sam Ng, Christopher Benz, Christina Yau, Stephen B. Baylin, Leslie Cope, Ludmila Danilova, James G. Herman, Moiz Bootwalla, Dennis T. Maglinte, Peter W. Laird, Timothy Triche, Daniel J. Weisenberger, David J. Van Den Berg, Nishant Agrawal, Justin Bishop, Paul C. Boutros, Jeff P Bruce, Lauren Averett Byers, Joseph Califano, Thomas E. Carey, Zhong Chen, Hui Cheng, Simion I. Chiosea, Ezra Cohen, Brenda Diergaarde, Ann Marie Egloff, Adel K. El-Naggar, Robert L. Ferris, Mitchell J. Frederick, Jennifer R. Grandis, Yan Guo, Robert I. Haddad, Peter S. Hammerman, Thomas Harris, D. Neil Hayes, Angela BY Hui, J. Jack Lee, Scott M. Lippman, Fei-Fei Liu, Jonathan B. McHugh, Jeff Myers, Patrick Kwok Shing Ng, Bayardo Perez-Ordonez, Curtis R. Pickering, Michael Prystowsky, Marjorie Romkes, Anthony D. Saleh, Maureen A. Sartor, Raja Seethala, Tanguy Y. Seiwert, Han Si, Aaron D. Tward, Carter Van Waes, Daryl M. Waggott, Maciej Wiznerowicz, Wendell Yarbrough, Jiexin Zhang, Zhixiang Zuo, Ken Burnett, Daniel Crain, Johanna Gardner, Kevin Lau, David Mallery, Scott Morris, Joseph Paulauskis, Robert Penny, Candance Shelton, Troy Shelton, Mark Sherman, Peggy Yena, Aaron D. Black, Jay Bowen, Jessica Frick, Julie M. Gastier-Foster, Hollie A. Harper, Tara M. Lichtenberg, Nilsa C. Ramirez, Lisa Wise, Erik Zmuda, Julien Baboud, Mark A. Jensen, Ari B. Kahn, Todd D. Pihl, David A. Pot, Deepak Srinivasan, Jessica S. Walton, Yunhu Wan, Robert Burton, Tanja Davidsen, John A. Demchok, Greg Eley, Martin L. Ferguson, Kenna R. Mills Shaw, Bradley A. Ozenberger, Margi Sheth, Heidi J. Sofia, Roy Tarnuzzer, Zhining Wang, Liming Yang, Jean Claude Zenklusen, Charles Saller, Katherine Tarvin, Chu Chen, Roni Bollag, Paul Weinberger, Wojciech Golusiński, Paweł Golusiński, Matthiew Ibbs, Konstanty Korski, Andrzej Mackiewicz, Wiktoria Suchorska, Bartosz Szybiak, Maciej Wiznerowicz, Ken Burnett, Erin Curley, Johanna Gardner, David Mallery, Robert Penny, Troy Shelton, Peggy Yena, Christina Beard, Colleen Mitchell, George Sandusky, Nishant Agrawal, Julie Ahn, Justin Bishop, Joseph Califano, Zubair Khan, Jeff P Bruce, Angela BY Hui, Jonathan Irish, Fei-Fei Liu, Bayardo Perez-Ordonez, John Waldron, Paul C. Boutros, Daryl M. Waggott, Jeff Myers, Scott M. Lippman, Sophie Egea, Carmen Gomez-Fernandez, Lynn Herbert, Carol R. Bradford, Thomas E. Carey, Douglas B. Chepeha, Andrea S. Haddad, Tamara R. Jones, Christine M. Komarck, Mayya Malakh, Jonathan B. McHugh, Jeffrey S. Moyer, Ariane Nguyen, Lisa A. Peterson, Mark E. Prince, Laura S. Rozek, Maureen A. Sartor, Evan G. Taylor, Heather M. Walline, Gregory T. Wolf, Lori Boice, Bhishamjit S. Chera, William K. Funkhouser, Margaret L. Gulley, Trevor G. Hackman, D. Neil Hayes, Michele C. Hayward, Mei Huang, W. Kimryn Rathmell, Ashley H. Salazar, William W. Shockley, Carol G. Shores, Leigh Thorne, Mark C. Weissler, Sylvia Wrenn, Adam M. Zanation, Simion I. Chiosea, Brenda Diergaarde, Ann Marie Egloff, Robert L. Ferris, Marjorie Romkes, Raja Seethala, Brandee T. Brown, Yan Guo, Michelle Pham, Wendell G. Yarbrough |
| Abstract |
Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the molecular architecture of HPV infection and its interaction with the host genome in head and neck cancers have not been comprehensively described. We profiled a cohort of 279 head and neck cancers with next generation RNA and DNA sequencing and show that 35 (12.5%) tumors displayed evidence of high-risk HPV types 16, 33, or 35. Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript abundance and splicing, and both inter- and intrachromosomal rearrangements. Many of these events involved genes with documented roles in cancer. Cancers with integrated vs. nonintegrated HPV displayed different patterns of DNA methylation and both human and viral gene expressions. Together, these data provide insight into the mechanisms by which HPV interacts with the human genome beyond expression of viral oncoproteins and suggest that specific integration events are an integral component of viral oncogenesis. |
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X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley demographics
The data shown below were compiled from readership statistics for 414 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Mexico | 2 | <1% |
| Denmark | 2 | <1% |
| Japan | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Colombia | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 400 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 90 | 22% |
| Researcher | 66 | 16% |
| Student > Bachelor | 44 | 11% |
| Student > Master | 41 | 10% |
| Student > Doctoral Student | 27 | 7% |
| Other | 61 | 15% |
| Unknown | 85 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 94 | 23% |
| Agricultural and Biological Sciences | 92 | 22% |
| Medicine and Dentistry | 84 | 20% |
| Immunology and Microbiology | 10 | 2% |
| Computer Science | 9 | 2% |
| Other | 29 | 7% |
| Unknown | 96 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 117. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2025.
All research outputs
#458,051
of 34,601,305 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#7,529
of 119,282 outputs
Outputs of similar age
#3,774
of 300,952 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#114
of 948 outputs
Altmetric has tracked 34,601,305 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 119,282 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.1. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 948 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.