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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Single Cell Electrochemiluminescence Imaging: From the Proof-of-Concept to Disposable Device-Based Analysis
|
|---|---|
| Published in |
Journal of the American Chemical Society, November 2017
|
| DOI | 10.1021/jacs.7b09260 |
| Pubmed ID | |
| Authors |
Giovanni Valenti, Sabina Scarabino, Bertrand Goudeau, Andreas Lesch, Milica Jović, Elena Villani, Milica Sentic, Stefania Rapino, Stéphane Arbault, Francesco Paolucci, Neso Sojic |
| Abstract |
We report here the development of coreactant-based electrogenerated chemiluminescence (ECL) as a surface-confined microscopy to image single cells and their membrane proteins. Labeling the entire cell membrane allows to demon-strate that, by contrast with fluorescence, ECL emission is only detected from fluorophores located in the immediate vicinity of the electrode surface (i.e. 1-2 µm). Then, to present the potential diagnostic applications of our approach, we selected carbon nanotubes (CNT)-based inkjet-printed disposable electrodes for the direct ECL imaging of a labeled plasma receptor over-expressed on tumor cells. The ECL fluorophore was linked to an antibody and enabled to localize the ECL generation on the cancer cell membrane in close proximity to the electrode surface. Such a result is intrinsically associated to the unique ECL mechanism and is rationalized by considering the limited lifetimes of the electrogenerated coreactant radicals. The electrochemi-cal stimulus used for luminescence generation does not suffer from background signals, such as the typical auto-fluorescence of biological samples. The presented surface-confined ECL microscopy should find promising applications in ultrasensitive single cell imaging assays. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 3 | 43% |
| Italy | 1 | 14% |
| United States | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 57% |
| Members of the public | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 88 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 18% |
| Researcher | 13 | 15% |
| Student > Master | 9 | 10% |
| Professor > Associate Professor | 6 | 7% |
| Student > Doctoral Student | 4 | 5% |
| Other | 11 | 13% |
| Unknown | 29 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 31 | 35% |
| Engineering | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Physics and Astronomy | 3 | 3% |
| Chemical Engineering | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 38 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2023.
All research outputs
#3,016,771
of 25,080,471 outputs
Outputs from Journal of the American Chemical Society
#8,908
of 65,928 outputs
Outputs of similar age
#55,396
of 338,117 outputs
Outputs of similar age from Journal of the American Chemical Society
#124
of 574 outputs
Altmetric has tracked 25,080,471 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 65,928 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,117 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 574 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.