| Title |
Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
|
|---|---|
| Published in |
Epigenetics & Chromatin, October 2014
|
| DOI | 10.1186/1756-8935-7-28 |
| Pubmed ID | |
| Authors |
Rachel Edgar, Powell Patrick Cheng Tan, Elodie Portales-Casamar, Paul Pavlidis |
| Abstract |
DNA methylation is thought to play an important role in the regulation of mammalian gene expression, partly based on the observation that a lack of CpG island methylation in gene promoters is associated with high transcriptional activity. However, the CpG island methylation level only accounts for a fraction of the variance in gene expression, and methylation in other domains is hypothesized to play a role. We hypothesized that regions of very high stability in methylation would exist and provide biological insight into the role of methylation both within and outside CpG islands. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 4 | 15% |
| United States | 3 | 12% |
| Spain | 3 | 12% |
| Canada | 3 | 12% |
| United Kingdom | 3 | 12% |
| Germany | 2 | 8% |
| Switzerland | 1 | 4% |
| Unknown | 7 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 13 | 50% |
| Members of the public | 10 | 38% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 3 | 2% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| New Zealand | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 120 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 29% |
| Researcher | 25 | 19% |
| Student > Master | 20 | 16% |
| Student > Doctoral Student | 9 | 7% |
| Student > Bachelor | 9 | 7% |
| Other | 17 | 13% |
| Unknown | 12 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 36% |
| Biochemistry, Genetics and Molecular Biology | 33 | 26% |
| Medicine and Dentistry | 12 | 9% |
| Computer Science | 4 | 3% |
| Nursing and Health Professions | 2 | 2% |
| Other | 10 | 8% |
| Unknown | 21 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2020.
All research outputs
#2,473,443
of 25,654,806 outputs
Outputs from Epigenetics & Chromatin
#74
of 617 outputs
Outputs of similar age
#27,601
of 273,945 outputs
Outputs of similar age from Epigenetics & Chromatin
#2
of 13 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 617 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,945 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.