Title |
Further in vitro evaluation of antiradical and antimicrobial activities of phytol
|
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Published in |
Natural Product Research, January 2014
|
DOI | 10.1080/14786419.2013.869692 |
Pubmed ID | |
Authors |
B. Pejin, A. Savic, M. Sokovic, J. Glamoclija, A. Ciric, M. Nikolic, K. Radotic, M. Mojovic |
Abstract |
The antiradical activity of phytol was evaluated by electron paramagnetic resonance towards hydroxyl radical (·OH), superoxide anion radical (·O2(-)), methoxy radical (·CH2OH), carbon-dioxide anion radical (·CO2(-)), as well as towards nitric-oxide radical (·NO) and 2,2-diphenyl-1-picrylhydrazyl (·DPPH) radical. It reduced the production of all tested radicals showing more promising activity against ·CO2(-), ·CH2OH and ·DPPH radicals (56%, 50% and 48%, respectively) in comparison with ·NO, ·O2(-) and ·OH radicals (38%, 23% and 15%, respectively). The antimicrobial activity of phytol was evaluated by the microdilution method against eight bacterial and eight fungal strains. To varying degrees, it was proven to be active against all tested bacteria and fungi (MIC 0.003-0.038 mg/mL and MBC 0.013-0.052 mg/mL, MIC 0.008-0.016 mg/mL and MFC 0.090-0.520 mg/mL, respectively). According to the obtained results, medical foods containing phytol may support development of new therapies for heart disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Serbia | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 99 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 18% |
Student > Master | 13 | 13% |
Researcher | 12 | 12% |
Student > Bachelor | 10 | 10% |
Student > Doctoral Student | 8 | 8% |
Other | 14 | 14% |
Unknown | 27 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 15 | 15% |
Biochemistry, Genetics and Molecular Biology | 14 | 14% |
Chemistry | 14 | 14% |
Medicine and Dentistry | 8 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
Other | 16 | 16% |
Unknown | 29 | 28% |