| Title |
CAR T cell therapy for multiple myeloma: where are we now and where are we headed?
|
|---|---|
| Published in |
Leukemia & Lymphoma, November 2017
|
| DOI | 10.1080/10428194.2017.1393668 |
| Pubmed ID | |
| Authors | |
| Abstract |
While recent progress has been made in the management of multiple myeloma, it remains a highly fatal malignancy especially among patients with relapsed-refractory disease. Immunotherapy with adoptive T cells targeting myeloma-associated antigens are at various stages of development and have brought about a new hope for cure. This is a review on the emerging field of adoptively transferred engineered T cell based approaches, with an in-depth focus on chimeric antigen receptors (CAR) targeting multiple myeloma. The recent results from CAR T cells targeting B cell maturation antigen are encouraging but eventual resistance to the CAR T cell therapies remain problematic. With newer approaches in therapies for multiple myeloma, the role of transplantation is evolved to form a platform for T cell therapies. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 53% |
| United Kingdom | 2 | 6% |
| Japan | 1 | 3% |
| India | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Mexico | 1 | 3% |
| Unknown | 11 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 75% |
| Scientists | 5 | 14% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 14% |
| Student > Ph. D. Student | 16 | 14% |
| Researcher | 13 | 12% |
| Student > Master | 11 | 10% |
| Other | 9 | 8% |
| Other | 13 | 12% |
| Unknown | 35 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 22% |
| Biochemistry, Genetics and Molecular Biology | 14 | 12% |
| Immunology and Microbiology | 10 | 9% |
| Agricultural and Biological Sciences | 7 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Other | 16 | 14% |
| Unknown | 37 | 33% |