In order to optimize a lead molecule for further development, bioisosteric replacements are generally adopted as one of the methods. Silicon appears to be the right choice as carbon isostere, because of similarity in chemical properties. Silicon could be strategically introduced in a molecule so as to modulate its drug like properties providing medicinal chemists an unconventional strategy with a possibility of replacing carbon atom. Silicon can also be introduced to replace other heteroatoms and can also act as surrogate of functional groups such as olefin and amide. Present perspective focuses on the opportunities that silicon incorporation offers in drug discovery with an emphasis on case studies where introduction of silicon has created a benefit over its analog. We have tried to highlight all the recent developments in the field and briefly touched up on the challenges associated with them.
Pharmacology, Toxicology and Pharmaceutical Science
8
4%
Agricultural and Biological Sciences
5
3%
Biochemistry, Genetics and Molecular Biology
4
2%
Engineering
4
2%
Other
7
4%
Unknown
74
38%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2026.
All research outputs
#1,577,923
of 33,403,089 outputs
Outputs from Journal of Medicinal Chemistry
#418
of 27,279 outputs
Outputs of similar age
#24,034
of 361,662 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#3
of 134 outputs
Altmetric has tracked 33,403,089 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,279 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 134 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.
