Jennifer Jao, Deborah Kacanek, Paige L Williams, Mitchell E Geffner, Elizabeth G Livingston, Rhoda S Sperling, Kunjal Patel, Arlene D Bardeguez, Sandra K Burchett, Nahida Chakhtoura, Gwendolyn B Scott, Russell B Van Dyke, Elaine J Abrams, Ram Yogev, Margaret Ann Sanders, Kathleen Malee, Scott Hunter, William Shearer, Mary Paul, Norma Cooper, Lynnette Harris, Murli Purswani, Emma Stuard, Anna Cintron, Ana Puga, Dia Cooley, Patricia A Garvie, James Blood, William Borkowsky, Sandra Deygoo, Marsha Vasserman, Arry Dieudonne, Linda Bettica, Katherine Knapp, Kim Allison, Megan Wilkins, Midnela Acevedo-Flores, Lourdes Angeli-Nieves, Vivian Olivera, Stephan Kohlhoff, Ava Dennie, Susan Bewley, Russell Van Dyke, Karen Craig, Patricia Sirois, Marilyn Crain, Paige Hickman, Dan Marullo, Stephen A Spector, Kim Norris, Sharon Nichols, Elizabeth McFarland, Carrie Chambers, Jenna Wallace, Emily Barr, Mobeen Rathore, Kristi Stowers, Saniyyah Mahmoudi, Ann Usitalo, Karen Hayani, Kenneth Rich, Lourdes Richardson, Renee Smith, Charles Mitchell, Sady Dominguez, Claudia Florez, Toni Frederick, Mariam Davtyan, Guadalupe Morales-Avendano, Zoe M Rodriguez, Ibet Heyer, Nydia Scalley Trifilio, G B Scott, R Tuomala, E Smith, H Watts, K M Oden, Y Huo, K Patel, E A Barr, A Bardeguez, S K Burchett, E Livingston, A M Stek, M T Basar, A Hernandez, A Jennings, T R Cressey, J Bryant, Ruth Tuomala, Elizabeth Smith, KaSaundra M Oden, Deborah Kacanek, Erin Leister, David E Shapiro, Emily A Barr, Diane W Wara, Arlene Bardeguez, Sandra K Burchett, Jenny Guiterrez, Kathleen Malee, Ann, H Robert, Alice M Stek, Patricia Tanjutco, Yvonne Bryson, Michael T Basar, Hernandez Adriane, Amy Jennings, Tim R Cressey, Jennifer Bryant, Arlene D Bardeguez, Linda Bettica, Charmane Calilap-Bernardo, Alice Higgins, Gina Silva, Sreedhar Gaddipati, Stephen A Spector, Andrew Hull, Mary Caffery, Jean Manning, Elizabeth Livingston, Margaret Donnelly, Joan Wilson, Julia Giner, Nancy Karthas, Lisa Tucker, Arlene Buck, Catherine Kneut, Sandra Deygoo, Aditya Kaul, Maryam Minter, Siham Akleh, Amanda Robson, Jane Hitti, Corry Venema-Weiss, Anna Klastorin, Karen L Bruder, Gail Lewis, Denise Casey, Sara Parker, Rachel Scott, Patricia Tanjutco, Vanessa Emmanuel, Antonio Mimoso, Rodrigo Diaz, Elvia Perez, Olga Pereira, Jennifer Griffin, Paul Ogburn, Alice Stek, Francoise Kramer, LaShonda Spencer, Andrea Kovacs, Mobeen Rathore, Isaac Delke, Geri Thomas, Barbara Millwood, Alisa Katai, Tara Kennedy, Kay Kinzie, Jenna Wallace, Julie Schmidt, Helen Cejtin, Maureen McNichols, Judith Senka, Deborah Cohan, Jean Anderson, Eileen Sheridan-Malone, Chritina Tolentino-Balbridge, Janielle Jackson-Alvarez, David Michalik, Jagmohan S Batra, Douglas Watson, Maria Johnson, Corinda Hilyard, Robert Maupin, Chi Dola, Yvette Luster, Sheila Bradford, Alan Tita, Micky Parks, Sharan Robbins, Edwin Thorpe, Katherine Knapp, Pamela Finnie, Nina Sublette, Carmen D Zorrilla, Vivian Tamayo-Agrait, Rodney Wright, Sharon Cormier, Katherine Luzuriaga

Pregnancy outcomes of perinatally HIV-infected women (PHIV) are poorly defined. We compared preterm delivery and birth weight (BW) outcomes [low BW (LBW, <2500 g), small-for-gestational-age (SGA), and BW z-scores (BWZ)] in HIV-exposed uninfected infants of PHIV vs. non-perinatally HIV-infected (NPHIV) pregnant women in the PHACS SMARTT or IMPAACT P1025 studies. Mixed effects models were fit to assess the association of maternal PHIV status with infant BWZ; log binomial models were used to estimate adjusted relative risks (aRR) for dichotomous outcomes. Age-stratified analyses were also performed. From 1998-2013, 2,270 HIV-infected pregnant women delivered 2,692 newborns (270 born to PHIV and 2,422 to NPHIV women). PHIV women were younger, (mean age 21 vs. 25 years, p<0.01), more likely to have a pregnancy CD4 count <200 cells/mm3 (19% vs. 11%, p=0.01), delivery HIV RNA level ≥400 copies/mL (28% vs. 17%, p<0.01), and receipt of ≥3-class antiretroviral therapy during pregnancy (23% vs. 2%, p<0.01). No associations between maternal PHIV status and preterm delivery, SGA, or LBW were observed. After adjustment, BWZ was 0.12 lower in infants of PHIV vs. NPHIV women (adjusted mean: -0.45 vs. -0.33, p=0.04). Amongst women 23-30 years old (n=1,770), maternal PHIV was associated with LBW (aRR=1.74, 95% Confidence Interval: 1.18, 2.58, p=0.03). The overall lack of association between maternal PHIV status and preterm delivery or infant BW outcomes is reassuring. The higher rates of LBW observed in 23-30 year old PHIV women warrants further mechanism-based investigations as this is a rapidly growing and aging population worldwide.