| Title |
Composition, Roles, and Regulation of Cullin-Based Ubiquitin E3 Ligases
|
|---|---|
| Published in |
The Arabidopsis Book / American Society of Plant Biologists, November 2014
|
| DOI | 10.1199/tab.0175 |
| Pubmed ID | |
| Authors | |
| Abstract |
Due to their sessile nature, plants depend on flexible regulatory systems that allow them to adequately regulate developmental and physiological processes in context with environmental cues. The ubiquitin proteasome pathway, which targets a great number of proteins for degradation, is cellular tool that provides the necessary flexibility to accomplish this task. Ubiquitin E3 ligases provide the needed specificity to the pathway by selectively binding to particular substrates and facilitating their ubiquitylation. The largest group of E3 ligases known in plants is represented by CULLIN-REALLY INTERESTING NEW GENE (RING) E3 ligases (CRLs). In recent years, a great amount of knowledge has been generated to reveal the critical roles of these enzymes across all aspects of plant life. This review provides an overview of the different classes of CRLs in plants, their specific complex compositions, the variety of biological processes they control, and the regulatory steps that can affect their activities. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Germany | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Kenya | 1 | <1% |
| Israel | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 23% |
| Student > Bachelor | 16 | 13% |
| Researcher | 16 | 13% |
| Student > Master | 15 | 12% |
| Student > Doctoral Student | 9 | 7% |
| Other | 14 | 11% |
| Unknown | 24 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 65 | 53% |
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Chemistry | 4 | 3% |
| Environmental Science | 1 | <1% |
| Computer Science | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 28 | 23% |