Changes in histone post-translational modifications are associated with epigenetic states that define distinct patterns of gene expression. It remains unclear whether epigenetic information can be transmitted through histone modifications independently of specific DNA sequence, DNA methylation, or RNAi. Here we show that, in the fission yeast Schizosaccharomyces pombe, ectopically induced domains of histone H3 lysine 9 methylation (H3K9me), a conserved marker of heterochromatin, are inherited through several mitotic and meiotic cell divisions after removal of the sequence-specific initiator. The putative JmjC domain H3K9 demethylase, Epe1, and the chromodomain of the H3K9 methyltransferase, Clr4/Suv39h play opposing roles in maintaining silent H3K9me domains. These results demonstrate how a direct 'read-write' mechanism involving Clr4 propagates histone modifications and allows histones to act as carriers of epigenetic information.
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2024.
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#1,602,282
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#24,874
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#17,663
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Outputs of similar age from Science
#286
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Altmetric has tracked 32,805,761 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,740 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 800 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
