This study aimed to document the vitamin D status of HIV-infected individuals across a wide latitude range in one country and to examine associated risk factors for low vitamin D. Using data from patients attending four HIV specialist clinics across a wide latitude range in Australia, we constructed logistic regression models to investigate risk factors associated with 25(OH)D<75 nmol/L. 1788 patients were included; 87% were male, 76% Caucasian and 72% on antiretroviral therapy. The proportion with 25(OH)D<50 nmol/L was 27%, and <75 nmol/L was 54%. Living in Melbourne compared to Cairns (adjusted odds ratio (aOR) 3.30; 95%CI 2.18, 4.99, p<0.001) and non-Caucasian origin (aOR 2.82, 95%CI 2.12, 3.75, p<0.001) was associated with an increased risk, while extreme UV index compared to low UV index was associated with a reduced risk (aOR 0.33; 95%CI 0.20, 0.55, p<0.001) of 25(OH)D <75 nmol/L. In those with biochemistry available (n=1117), antiretroviral therapy was associated with 25(OH)D <75 nmol/L, however, this association was modified by serum cholesterol status. Location and UV index were the strongest factors associated with 25(OH)D <75 nmol/L. Cholesterol, the product of an alternative steroid pathway with a common precursor steroid, modified the effect of antiretroviral therapy on serum 25(OH)D. This article is protected by copyright. All rights reserved.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2014.
All research outputs
#9,193,638
of 34,410,315 outputs
Outputs from Photochemistry & Photobiology
#1,183
of 3,504 outputs
Outputs of similar age
#99,646
of 421,891 outputs
Outputs of similar age from Photochemistry & Photobiology
#14
of 23 outputs
Altmetric has tracked 34,410,315 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,504 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 66% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
