Title |
The Biology of Cancer Exosomes: Insights and New Perspectives
|
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Published in |
Cancer Research, November 2017
|
DOI | 10.1158/0008-5472.can-17-0994 |
Pubmed ID | |
Authors |
Carolina F. Ruivo, Bárbara Adem, Miguel Silva, Sónia A. Melo |
Abstract |
Exosomes are a subclass of extracellular vesicles involved in intercellular communication that are released by all cell types, including cancer cells. Cancer exosomes carry malignant information in the form of proteins, lipids, and nucleic acids that can reprogram recipient cells. Exosomes have emerged as putative biological mediators in cancer contributing to major steps of disease progression. A leading role exists for cancer exosomes in specific aspects of tumor progression: modulation of immune response, tumor microenvironment reprogramming, and metastasis. This review will address the functions attributed to cancer exosomes in these three aspects of cancer biology, highlighting recent advances and potential limitations. Finally, we explore alternative strategies to develop better models to study cancer exosomes biology. Cancer Res; 77(23); 1-9. ©2017 AACR. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 43% |
Japan | 1 | 14% |
Korea, Republic of | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 363 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 16% |
Researcher | 46 | 13% |
Student > Master | 45 | 12% |
Student > Bachelor | 36 | 10% |
Student > Doctoral Student | 23 | 6% |
Other | 46 | 13% |
Unknown | 108 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 105 | 29% |
Medicine and Dentistry | 45 | 12% |
Agricultural and Biological Sciences | 30 | 8% |
Chemistry | 13 | 4% |
Engineering | 12 | 3% |
Other | 44 | 12% |
Unknown | 114 | 31% |