Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by the same neurons. Surprisingly, prior studies have shown that both receptors stimulate cyclic AMP (cAMP) accumulation, presenting an enigma of how mushroom body neurons distinguish between acquisition and forgetting signals. Here, we surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis. However, the Damb receptor uniquely activates Gq to mobilize Ca(2+) signaling with greater efficiency and dopamine sensitivity. The knockdown of Gαq with RNAi in the mushroom bodies inhibits forgetting but has no effect on acquisition. Our findings identify a Damb/Gq-signaling pathway that stimulates forgetting and resolves the opposing effects of dopamine on acquisition and forgetting.
This research output has an Altmetric Attention Score of 70. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2019.
All research outputs
#695,168
of 28,832,041 outputs
Outputs from Cell Reports
#1,379
of 14,872 outputs
Outputs of similar age
#12,997
of 348,641 outputs
Outputs of similar age from Cell Reports
#38
of 323 outputs
Altmetric has tracked 28,832,041 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,872 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.3. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 323 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.
