RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation

Overview of attention for article published in Cell Cycle, October 2014

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bc the RFTS domain of DNMT1 is a negative regulator normally released by UHRF1, if you delete RFTS, you get an oncogenic gain of function allele…. and this was not even Bo-Kuan Wu’s best paper!

@doctorconnor I recall that @CharlesMBrenner published some work on the effects of mutant DNMT1 https://t.co/cMdnGDICQI

Pubmed: RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation. http://t.co/pPuyzS5mhp

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