Near-infrared (NIR) fluorescent dyes with favorable photophysical properties are highly useful for bioimaging, but such dyes are still rare. Here, we describe the development of a unique class of NIR dyes via modifying the rhodol-scaffold with fused tetrahydroquinoxaline rings. These new dyes showed large Stokes shifts (>110 nm). Among them, WR3, WR4, WR5 and WR6 displayed high fluorescence quantum yields and excellent photostability in aqueous solutions. Moreover, their fluorescence properties were tunable by easy modifications on the phenolic hydroxyl group. Based on WR6, two NIR fluorescent turn-on probes, WSP-NIR and SeSP-NIR, were devised for the detection of H2S. The probe SeSP-NIR was applied in visualizing intracellular H2S. The dyes presented herein are expected to be useful fluorophore scaffolds in the development of new NIR probes for bioimaging.
Pharmacology, Toxicology and Pharmaceutical Science
3
4%
Agricultural and Biological Sciences
3
4%
Engineering
2
3%
Other
4
6%
Unknown
25
35%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2024.
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#849,658
of 34,400,738 outputs
Outputs from Angewandte Chemie. International Edition
#712
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Outputs of similar age
#14,505
of 492,338 outputs
Outputs of similar age from Angewandte Chemie. International Edition
#18
of 730 outputs
Altmetric has tracked 34,400,738 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 61,737 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 730 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.
