| Title |
The El Escorial criteria: Strengths and weaknesses
|
|---|---|
| Published in |
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, December 2014
|
| DOI | 10.3109/21678421.2014.964258 |
| Pubmed ID | |
| Authors |
Federica Agosta, Ammar Al-Chalabi, Massimo Filippi, Orla Hardiman, Ryuji Kaji, Vincent Meininger, Imaharu Nakano, Pamela Shaw, Jeremy Shefner, Leonard H. van den Berg, Albert Ludolph, The WFN Research Group on ALS/MND |
| Abstract |
The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Philippines | 1 | <1% |
| France | 1 | <1% |
| Unknown | 209 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 14% |
| Student > Bachelor | 22 | 10% |
| Student > Master | 22 | 10% |
| Student > Doctoral Student | 20 | 9% |
| Researcher | 16 | 8% |
| Other | 41 | 19% |
| Unknown | 61 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 70 | 33% |
| Neuroscience | 22 | 10% |
| Biochemistry, Genetics and Molecular Biology | 14 | 7% |
| Nursing and Health Professions | 7 | 3% |
| Agricultural and Biological Sciences | 6 | 3% |
| Other | 23 | 11% |
| Unknown | 70 | 33% |