Rare mutations in LDLR and APOA5 genes increase risk of early-onset heart attack. LDLR mutation carriers have higher LDL cholesterol, while APOA5 mutation carriers have higher triglycerides. #HeartHealth #Genetics https://t.co/KE7Vr14aOv https://t.co/pt…
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الطفرات النادرة في جينات LDLR و APOA5 تزيد من خطر الإصابة بالنوبة القلبية في سن مبكرة. حاملي الطفرة LDLR لديهم كوليسترول LDL أعلى، بينما حاملي الطفرة APOA5 لديهم ترايجليسيريدات أعلى. #صحة_القلب #الجينات https://t.co/TnsUEIVXvx https://t.co/hlJyJlTfYF
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@JamesStein18 Sorry Jim, meant to respond earlier @Drlipid way more knowledgeable about the physiology Re genetics, yes, we showed that APOA5 mutations lead to not only higher TG but also up risk for early-onset MI https://t.co/eTWwyTdZvp https://t.…
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Kathiresan #AGBTph18 Genetic paths: case/controls n=5000/5000: LDLR 3.2x-fold '15 Nature https://t.co/aHpAh0SD8V