We present an approach for combining high resolution MRI-based myelin mapping with functional information from electroencephalography (EEG) or magnetoencephalography (MEG). The main contribution to the primary currents detectable with EEG and MEG comes from ionic currents in the apical dendrites of cortical pyramidal cells, aligned perpendicular to the local cortical surface. We provide evidence from an in-vivo experiment that the known microstructural variation in myelinated pyramidal cell density across the cortex predicts the variation of the current density over individuals and thus is of functional relevance. Current dipole moments of pitch onset evoked response fields (ERFs) were source localised by means of a variational Bayesian equivalent current dipole algorithm. The myeloarchitecture was estimated indirectly from individual high resolution quantitative multi-parameter maps (MPMs) acquired at 800μm isotropic resolution. Myelin estimates across cortical areas correlated positively with dipole magnitude. This correlation was spatially specific: regions of interest in auditory cortex provided significantly better models than those covering whole hemispheres. Based on the MPM data we identified the auditory cortical area TE1.2 as the most likely origin of the pitch ERFs measured by MEG. We can now proceed to exploit the higher spatial resolution of quantitative MPMs to identify the cortical origin of M/EEG signals, inform M/EEG source reconstruction and explore structure-function relationships at the fine structural level in the living human brain.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2014.
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#7,491,411
of 29,841,715 outputs
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#4,807
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Outputs of similar age
#82,386
of 375,775 outputs
Outputs of similar age from NeuroImage
#57
of 161 outputs
Altmetric has tracked 29,841,715 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 12,821 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
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