Emerging research has highlighted the importance of leptin in growth and development, independent of its essential role in the maintenance of hunger and satiety. Alterations in maternal-placental-fetal leptin exchange may modify the development of the fetus and contribute to the increased risk of developing disease in adulthood. In addition, leptin also plays an important role in reproductive functions, with plasma leptin concentrations rising in pregnant women, peaking during the third trimester. Elevated plasma leptin concentrations occur at the completion of organogenesis, and research in animal models have demonstrated that leptin is involved in the development and maturation of a number of organs including the heart, brain, kidneys and pancreas. Elevated maternal plasma leptin is associated with maternal obesity, and reduced fetal plasma leptin is correlated with intrauterine growth restriction. Alterations in plasma leptin during development may be associated with an increased risk of developing a number of adulthood diseases including cardiovascular, metabolic, and renal diseases via altered fetal development and organogenesis. Importantly, research has shown that leptin antagonism after birth significantly reduces maturation of numerous organs. Conversely, restoration of the leptin deficiency after birth in growth restricted animals restores the offspring's body weight and improves organogenesis. Therefore, leptin appears to play a major role in organogenesis which may adversely affect the risk of developing a number of diseases in adulthood. Greater understanding of the role of leptin during development may therefore assist in the prevention and treatment of a number of disease states that occur in adulthood.
Pharmacology, Toxicology and Pharmaceutical Science
4
3%
Other
14
10%
Unknown
38
28%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2020.
All research outputs
#7,213,116
of 34,358,242 outputs
Outputs from American Journal of Physiology: Endocrinology & Metabolism
#1,185
of 4,816 outputs
Outputs of similar age
#78,612
of 412,510 outputs
Outputs of similar age from American Journal of Physiology: Endocrinology & Metabolism
#5
of 34 outputs
Altmetric has tracked 34,358,242 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,816 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 412,510 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.
