| Title |
Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?
|
|---|---|
| Published in |
Critical Care, December 2015
|
| DOI | 10.1186/s13054-014-0717-4 |
| Pubmed ID | |
| Authors |
Anna J Wetz, Eva M Richardt, Saskia Wand, Nils Kunze, Hanna Schotola, Michael Quintel, Anselm Bräuer, Onnen Moerer |
| Abstract |
IntroductionPostoperative acute kidney injury (AKI) is a frequently observed complication after on-pump cardiac surgery (CS) and associated with adverse patient outcome. Early identification of patients at risk is essential for the prevention of CS-AKI. This study analyzed if urinary tissue-inhibitor of metalloproteinase 2 (TIMP-2) multiplied with urine insulin like growth factor binding protein 7 (IGFBP-7) is an adequate diagnostic test to identify early AKI after on-pump cardiac surgery.MethodsIn 42 patients undergoing coronary artery bypass grafting (CABG)-surgery we surveyed individual risk factors for AKI and defined AKI by applying the KDIGO-classification during surgery day and the following two postoperative days. Concentrations of urinary TIMP-2 multiplied by IGFBP-7 were recorded at four time points: at baseline pre-surgery, at the end of surgery, 4 hours after cardio pulmonary bypass (CPB) and at 8:00 am on the first postoperative day.ResultsIn total, 38% of the patients suffered from AKI. The results showed a median baseline [TIMP-2] x [IGFBP-7] concentration of 0.3 (ng/ml)2/1000, decreasing at the end of surgery, increasing at the next measure point 4 hours after CPB and further on the first postoperative day. On the first postoperative day, patients with AKI had significantly higher concentrations of [TIMP-2] x [IGFBP-7]. On the day of surgery it did not significantly differ between KDIGO 0 and KDIGO 1 to 2. Previously published cut-off points of 0.3 and 2 were not confirmed in our study cohort.Conclusion[TIMP-2] x [IGFBP-7] can be used as a diagnostic test to identify patients at increased risk of AKI after cardiac surgery on the first postoperative day. At earlier time points no significant difference in [TIMP-2] x [IGFBP-7] concentration was found between patients classified as KDIGO 0 or KDIGO 1¿2.Trial registrationGerman Clinical Trials Register (DRKS) DRKS00005457. Registered 26 November 2013. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 13% |
| Colombia | 1 | 7% |
| Argentina | 1 | 7% |
| Ecuador | 1 | 7% |
| Guinea | 1 | 7% |
| New Zealand | 1 | 7% |
| Venezuela, Bolivarian Republic of | 1 | 7% |
| Turkey | 1 | 7% |
| United Kingdom | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 4 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 40% |
| Scientists | 4 | 27% |
| Practitioners (doctors, other healthcare professionals) | 3 | 20% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 84 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 16% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Bachelor | 10 | 12% |
| Other | 6 | 7% |
| Student > Master | 6 | 7% |
| Other | 20 | 23% |
| Unknown | 19 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 56% |
| Agricultural and Biological Sciences | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Nursing and Health Professions | 2 | 2% |
| Engineering | 2 | 2% |
| Other | 4 | 5% |
| Unknown | 21 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2022.
All research outputs
#2,614,971
of 25,374,917 outputs
Outputs from Critical Care
#2,282
of 6,554 outputs
Outputs of similar age
#41,879
of 395,418 outputs
Outputs of similar age from Critical Care
#175
of 466 outputs
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