Catalytic Asymmetric Synthesis of Trifluoromethylated γ‐Amino Acids through the Umpolung Addition of Trifluoromethyl Imines to Carboxylic Acid Derivatives
Published in
Angewandte Chemie. International Edition, January 2018
Enabled by the discovery of novel cinchona alkaloid-derived chiral phase-transfer catalysts, highly chemo-, regio-, diastereo- and enantioselective umpolung additions of trifluoromethyl imines to α, β-unsaturated N-acylpyrroles were realized. With a catalyst loading ranging from 0.2 to 5.0 mol%, this new catalytic asymmetric transformation provides facile and high-yield access to highly enantiomerically enriched chiral trifluoromethylated γ-amino acids and γ-lactams.
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2018.
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