Title |
Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp. viridis Bark
|
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Published in |
Journal of Natural Products, April 2017
|
DOI | 10.1021/acs.jnatprod.6b00805 |
Pubmed ID | |
Authors |
Miroslav Novakovic, Jasmina Nikodinovic-Runic, Jovana Veselinovic, Tatjana Ilic-Tomic, Vera Vidakovic, Vele Tesevic, Slobodan Milosavljevic |
Abstract |
Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of cancer cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and IIα for an in silico investigation. |
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