Title |
The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis
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Published in |
Disease Markers, April 2014
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DOI | 10.1155/2014/362708 |
Pubmed ID | |
Authors |
Maja Živković, Nada Starčević Čizmarević, Luca Lovrečić, Inge Klupka-Sarić, Aleksandra Stanković, Iva Gašparović, Polona Lavtar, Evica Dinčić, Ljiljana Stojković, Gorazd Rudolf, Saša Šega Jazbec, Olivio Perković, Osman Sinanović, Juraj Sepčić, Miljenko Kapović, Borut Peterlin, Smiljana Ristić |
Abstract |
Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Student > Bachelor | 4 | 12% |
Other | 4 | 12% |
Researcher | 4 | 12% |
Professor | 3 | 9% |
Other | 5 | 15% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 24% |
Neuroscience | 7 | 21% |
Medicine and Dentistry | 7 | 21% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Chemistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 24% |