Title |
Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action.
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Published in |
Current Topics in Medicinal Chemistry, January 2013
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DOI | 10.2174/15680266113136660198 |
Pubmed ID | |
Authors |
Višnja Popović, Jelena Živković, Slobodan Davidović, Milena Stevanović, Dejan Stojković |
Abstract |
Mycotherapy is defined as the study of the use of extracts and compounds obtained from mushrooms as medicines or health-promoting agents. The present review updates the recent findings on anticancer/antitumor agents derived from mushroom extracts and their metabolites. The increasing number of studies in the past few years revealed mushroom extracts as potent antitumor agents. Also, numerous studies were conducted on bioactive compounds isolated from mushrooms reporting the heteropolysaccharides, β-glucans, α-glucans, proteins, complexes of polysaccharides with proteins, fatty acids, nucleoside antagonists, terpenoids, sesquiterpenes, lanostanoids, sterols and phenolic acids as promising antitumor agents. Also, molecular mechanisms of cytotoxicity against different cancer cell lines are discussed in this review. Findings with Antrodia camphorata and Ganoderma lucidium extracts and isolated compounds are presented, as being the most deeply studied previously. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 16% |
Researcher | 9 | 14% |
Student > Ph. D. Student | 8 | 13% |
Other | 5 | 8% |
Student > Bachelor | 4 | 6% |
Other | 14 | 22% |
Unknown | 14 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 23% |
Medicine and Dentistry | 9 | 14% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Chemistry | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 7 | 11% |
Unknown | 16 | 25% |