| Title |
DCAF4, a novel gene associated with leucocyte telomere length
|
|---|---|
| Published in |
Journal of Medical Genetics, January 2015
|
| DOI | 10.1136/jmedgenet-2014-102681 |
| Pubmed ID | |
| Authors |
Massimo Mangino, Lene Christiansen, Rivka Stone, Steven C Hunt, Kent Horvath, Dan T A Eisenberg, Masayuki Kimura, Inge Petersen, Jeremy D Kark, Utz Herbig, Alex P Reiner, Athanase Benetos, Veryan Codd, Dale R Nyholt, Ronit Sinnreich, Kaare Christensen, Hisham Nassar, Shih-Jen Hwang, Daniel Levy, Veronique Bataille, Annette L Fitzpatrick, Wei Chen, Gerald S Berenson, Nilesh J Samani, Nicholas G Martin, Sarah Tishkoff, Nicholas J Schork, Kirsten Ohm Kyvik, Christine Dalgård, Timothy D Spector, Abraham Aviv |
| Abstract |
Leucocyte telomere length (LTL), which is fashioned by multiple genes, has been linked to a host of human diseases, including sporadic melanoma. A number of genes associated with LTL have already been identified through genome-wide association studies. The main aim of this study was to establish whether DCAF4 (DDB1 and CUL4-associated factor 4) is associated with LTL. In addition, using ingenuity pathway analysis (IPA), we examined whether LTL-associated genes in the general population might partially explain the inherently longer LTL in patients with sporadic melanoma, the risk for which is increased with ultraviolet radiation (UVR). |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 14% |
| United Kingdom | 2 | 14% |
| Kenya | 1 | 7% |
| Venezuela, Bolivarian Republic of | 1 | 7% |
| Mexico | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 6 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 86% |
| Scientists | 2 | 14% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 26% |
| Student > Bachelor | 11 | 14% |
| Other | 7 | 9% |
| Student > Master | 6 | 8% |
| Researcher | 5 | 6% |
| Other | 14 | 18% |
| Unknown | 16 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 19% |
| Medicine and Dentistry | 14 | 18% |
| Biochemistry, Genetics and Molecular Biology | 13 | 16% |
| Nursing and Health Professions | 4 | 5% |
| Psychology | 3 | 4% |
| Other | 11 | 14% |
| Unknown | 20 | 25% |