| Title |
Demyelinating CMT–what’s known, what’s new and what’s in store?
|
|---|---|
| Published in |
Neuroscience Letters, January 2015
|
| DOI | 10.1016/j.neulet.2015.01.059 |
| Pubmed ID | |
| Authors | |
| Abstract |
Inherited neuropathies known collectively as Charcot-Marie-Tooth disease are one of the most common inherited neurological conditions affecting ∼1 in 2500 people. A heterogenous disorder, CMT is divided into subtypes based on the pattern of inheritance and also by neurophysiological studies. Despite the clinical similarities among patients with demyelinating CMT, it is recognized that this group of disorders is both genetically and phenotypically heterogenous. Understanding the pathogenesis of these disorders requires an intimate knowledge of normal myelin development and homeostasis. Improvements in genetic testing techniques over the last 20 years have contributed majorly to the identification of specific genes, proteins, and molecular pathways that are providing the basis for understanding the disease processes and developing rational approaches to therapy. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| United Kingdom | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 99 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 19% |
| Researcher | 18 | 18% |
| Student > Bachelor | 15 | 15% |
| Student > Master | 10 | 10% |
| Other | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 24% |
| Biochemistry, Genetics and Molecular Biology | 18 | 18% |
| Medicine and Dentistry | 11 | 11% |
| Neuroscience | 7 | 7% |
| Engineering | 6 | 6% |
| Other | 8 | 8% |
| Unknown | 27 | 27% |