Title |
Vitamin E and Selenium Interrelations in the Diet of Atlantic Salmon (Salmo salar): Gross, Histological and Biochemical Deficiency Signs
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Published in |
Journal of Nutrition, July 1976
|
DOI | 10.1093/jn/106.7.892 |
Pubmed ID | |
Authors |
Hugh A. Poston, Gerald F. Combs, Louis Leibovitz |
Abstract |
Either simultaneous or separate dietary deficiencies of vitamin E and selenium in Atlantic salmon during first 4 weeks of feeding caused twice the mortality shown in fish fed both supplemental vitamin E (0.5 IU/g dry diet) and selenium (0.1 mug/g). Subsequent dietary repletion with both vitamin E and selenium significantly reduced mortality during the following 2 weeks. Larger salmon (0.9 g initial mean weight), with vitamin E deficiency with or without selenium resulted in the following deficiency signs: extreme anemia, pale gills, anisocytosis, poikilocytosis, elevated plasma protein, exudative diathesis, dermal depigmentation, in vitro ascorbic acid-stimulated peroxidation in hepatic microsomes, yellow-orange liver color, yellow-brown intestinal contents, enlarged gall bladder distended with dark green bile, low vitamin E in carcass and hepatic tissue, muscular dystrophy, increased carcass fat and water, and a response to handling characterized by a transitory fainting with interruption in swimming. A deficiency of dietary selenium suppressed plasma glutathione peroxidase activity. Supplemental selenium with vitamin E significantly increased tocopherol activity in hepatic, but not carcass tissues. Supplements of both vitamin E and selenium were necessary to prevent muscular dystrophy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 1% |
United States | 1 | 1% |
Unknown | 65 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 22% |
Student > Master | 9 | 13% |
Researcher | 8 | 12% |
Student > Bachelor | 6 | 9% |
Professor | 4 | 6% |
Other | 10 | 15% |
Unknown | 15 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 36% |
Medicine and Dentistry | 6 | 9% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Environmental Science | 2 | 3% |
Other | 9 | 13% |
Unknown | 20 | 30% |