| Title |
Effects of frequent marijuana use on memory-related regional cerebral blood flow
|
|---|---|
| Published in |
Pharmacology, Biochemistry & Behavior, May 2002
|
| DOI | 10.1016/s0091-3057(01)00771-7 |
| Pubmed ID | |
| Authors | |
| Abstract |
It is uncertain whether frequent marijuana use adversely affects human brain function. Using positron emission tomography (PET), memory-related regional cerebral blood flow was compared in frequent marijuana users and nonusing control subjects after 26+ h of monitored abstention. Memory-related blood flow in marijuana users, relative to control subjects, showed decreases in prefrontal cortex, increases in memory-relevant regions of cerebellum, and altered lateralization in hippocampus. Marijuana users differed most in brain activity related to episodic memory encoding. In learning a word list to criterion over multiple trials, marijuana users, relative to control subjects, required means of 2.7 more presentations during initial learning and 3.1 more presentations during subsequent relearning. In single-trial recall, marijuana users appeared to rely more on short-term memory, recalling 23% more than control subjects from the end of a list, but 19% less from the middle. These findings indicate altered memory-related brain function in marijuana users. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 2 | 1% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 135 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 19% |
| Student > Bachelor | 26 | 18% |
| Student > Master | 15 | 10% |
| Student > Ph. D. Student | 14 | 10% |
| Other | 9 | 6% |
| Other | 31 | 21% |
| Unknown | 24 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 48 | 33% |
| Medicine and Dentistry | 21 | 14% |
| Neuroscience | 16 | 11% |
| Agricultural and Biological Sciences | 12 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 19 | 13% |
| Unknown | 27 | 18% |