This research aims to evaluate the predictive performance of a published allopurinol dosing tool. Allopurinol dose predictions were compared to the actual dose required to achieve serum urate (SU) <0.36 mmol L-1 using mean prediction error. The influence of patient factors on dose predictions was explored using multilinear regression. Allopurinol doses were over-predicted by the dosing tool, however, this was minimal in patients without diuretic therapy (MPE 63mg day-1 , 95%CI 40-87) compared to those receiving diuretics (MPE 295mg day-1 , 95%CI 260-330, p<0.0001). ABCG2 genotype (rs2231142, G>T) had an important impact on the dose predictions (MPE 201, 107, 15mg day-1 for GG, GT and TT, respectively, p<0.0001). Diuretic use and ABCG2 genotype explained 53% if the variability in prediction error (R2 =0.53, p=0.0004). The dosing tool produced acceptable maintenance dose predictions for patients not taking diuretics. Inclusion of ABCG2 genotype and a revised adjustment for diuretics would further improve the performance of the dosing tool.
Pharmacology, Toxicology and Pharmaceutical Science
3
23%
Medicine and Dentistry
3
23%
Biochemistry, Genetics and Molecular Biology
1
8%
Unknown
6
46%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2019.
All research outputs
#8,382,066
of 26,801,235 outputs
Outputs from British Journal of Clinical Pharmacology
#2,200
of 5,649 outputs
Outputs of similar age
#130,190
of 348,058 outputs
Outputs of similar age from British Journal of Clinical Pharmacology
#41
of 85 outputs
Altmetric has tracked 26,801,235 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 5,649 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,058 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
