| Title |
Snake Venoms and the Neuromuscular Junction
|
|---|---|
| Published in |
Seminars in Neurology, July 2004
|
| DOI | 10.1055/s-2004-830904 |
| Pubmed ID | |
| Authors |
Robert Lewis, Ludwig Gutmann |
| Abstract |
There are approximately 420 venomous species of snakes living on the earth. Their venoms, each unique, can affect multiple organ systems. The venoms have a predilection for the peripheral nervous system where the neuromuscular junction is a favorite target. Those venoms affecting the release of acetylcholine from the presynaptic membrane are called beta-neurotoxins and those affecting the postsynaptic membrane are called alpha-neurotoxins. alpha-Bungarotoxin has been used in quantitative studies of acetylcholine receptor density and turnover and for the assay of antibodies directed against the acetylcholine receptor. A unique feature of timber rattlesnake venom is its ability to cause clinical myokymia. This likely results from a blockade of voltage gated K+ antibodies. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Mexico | 1 | 2% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 17% |
| Student > Master | 7 | 13% |
| Student > Doctoral Student | 6 | 11% |
| Professor | 5 | 9% |
| Researcher | 5 | 9% |
| Other | 9 | 17% |
| Unknown | 13 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 26% |
| Agricultural and Biological Sciences | 12 | 22% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Immunology and Microbiology | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 15 | 28% |