TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes

Overview of attention for article published in Current Biology, January 2018

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In the past 5 years, breakthrough research initiated by @kmaessuman @WashUGenetics identified TIR-domains as ancient immune proteins that cleave NAD+ into the purine nucleotides ADPR, cADPR, or (the now-identified) 2'cADPR. (See their 2018 work at http…

RT @B3H3ALTHY: @nickmmark “These findings suggest that the primordial function of the TIR domain is the enzymatic cleavage of NAD+ and esta…

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes. https://t.co/uV9OmuYvlz

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes https://t.co/oGvC4oULwC

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